- Measurement of fibrinogen in plasma.
- Detection of low fibrinogen concentrations.
- Detection of elevated fibrinogen concentrations (> 4g/L):
- in clinical situations associated with inflammation.
- risk factor for cardiovascular disease and thrombosis.
- Hypofibrinogenemia, mainly associated with severe liver disease, and excessive consumption of fibrinogen (DIC, hyperfibrinolysis).
- Numerous variants of fibrinogen described, associated to asymptomatic cases or to cases with bleeding and/or thrombosis.