Resources

Hyphen-BioMed Product Literature

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1. HEMOCLOT
2. BIOPHEN
3. ZYMUTEST
4. HIT Assays
5. Microparticles
6. Veterinary
7. Human, Bovine and Misc. Sales Sheets
8. Technical Files
9. Posters
10. Evaluation of Hyphen BioMed Chromogenic Substrates vs Chromogenix Substrates
11. Industrial USP Heparin Reagents
12. Product Catalogs

1. HEMOCLOT

HEMOCLOT - Schemes 

• Updating Conventional Clotting Assays - HEMOCLOT Line
• The Most Updated Clotting Methods (Ref. ADP080A, ADP080K, ADP070A, ADP070K, ADP060A, ADP060K, ADP050A, ADP050K, ADP040A, ADP040K, ADP030A, ADP030K, ADP020A, ADP020K, ADP010A, ADP010K, ACK081K, ACK071K, ACK065K, ACK061K, ACK061L, ACK011K, ACK011L, ACK002K, ACK001K, ACK001L)
• The Modern Approach for Clotting Assays 
• The Central Role of Thrombin in Regulating Coagulation - Calibrators and Controls (Ref. ACK001K / ACK001L) 

• True Anti-Thrombin Clotting Activity of Direct Thrombin Inhibitors in Plasma Including Argatroban® (Ref. ACK002K)
• Direct Thrombin Inhibitors' Activity Measurement in Plasma (ref. ASC030K, ASC035K, ACK002K, A220202)
• New Assays for Safely Monitoring Hirudin and Direct Thrombin Inhibitors

Factors VII+X - HEMOCLOT VII+X 

• Highly Sensitive Assay for Measuring Factors VII+X in Human Plasma - HEMOCLOT VII+X (Ref. ACK051K)

Thrombin Time 

• The Reagent of Choice for all your Thrombin Time Applications - HEMOCLOT Thrombin time (T.T.) (Ref. ACK011K / ACK011L) 

Protein C/Protein S and AT III Pathways 

• Regulation of Blood Coagulation Through the Protein C / Protein S and AT lll Pathways - Quanti V-L (Ref. ACK065K) 

Factor V-Leiden 

• Measuring the APC Resistance associated with Factor V-L, Quantitatively - New Concept for Factor V-L (Ref. ACK065K / ACK065L)
• Measuring the APC Resistance associated with Factor V-L (Ref. ACK061K / ACK061L)
• Quantitative Assay for Measuring Factor V-Leiden Concentration in Plasma by its Resistance to the Action of Activated Protein C - Hemoclot Quanti-V-L (Ref. ACK065K)
• New Quantitative Assay for Factor V-Leiden - Measuring APC Ressistance Associated with Factor V-Leiden Quantitatively (Ref. ACK061K/ACK061L)
• Quantitative Measurement Of Factor V-Leiden With a New, One Step, Calibrated, Clotting Assay (Ref. ACK061K/ACK061L)
• Classification of Factor V-Leiden Carriers by Quantitatively Measuring it's Procoagulant Activity Comparatively to that of Factor V (Ref. ACK065K, ACK061K, ACK071K and ARK009A)
• Quantitative Measurement of Factor V Leiden in Heterozygous and Homozygous Patients for the R506Q Factor V Mutation (Ref. ACK065K, ACK061K, ACK071, ARK009A)
• Evaluation of a Novel Quantitative Assay for Factor V Leiden (Ref. ACK065K)

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2. BIOPHEN  

BIOPHEN - Schemes 

• Laboratory Assays for Anticoagulant/Antithrombotic Proteins (Ref. A221202, A221205, A221102, A221105, A222101, A223201 A223301)
• A Complete Line of Chromogenic Assays (Ref. A221402, A221304, A221202, A221205, A221705, A221605, A221102, A221105, A221111, A221003,A221006, A221505, A222101, A223201, A223301)
• The Most Complete Range of Chromogenic Assays for Heparin
• Hyphen BioMed Offers a Complete Range of Kits for Measuring Heparin Concentrations (Ref. A221003, A221006,A221010, A221020, A221025, A222001, A222301, A222201, A223001, 223701, 223101, A223501, A222501, A224001, ARK040A, ARK040D, ARK040E)
• The Leading Company for Updated Chromogenic Assays 

Factor VIII:C 

• BIOPHEN VIII:C, Factor VIII:C Chromogenic assay - A Reference Method, Which Can Be Used With Manual or Automated Techniques (Ref. A221402)
• Measurement of Factor VIII:C Activity in Human Plasma or in Factor VIII :C Concentrates (Ref. A221402)
• Factors Affecting the Factor VIII:C Reactivity When Tested in Purified Systems With Chromogenic Assays (Ref. A221402) 

Heparin 3 and 6 

• Measurement of Heparin Concentrations in Human Plasma Concentrations (Ref. A221003 / A221006) 

Anti-Xa Heparin Assays 

• Comparison of Two Anti-Xa Heparin Assays That Use a Single (Hybrid) Calibration Curve for Unfractionated and Low Molecular Weight Heparin (Ref. A221010) 

Factor IX and X 

• New Standardized Chromogenic Assays for Automated Measurements of FIX or FIXa in Plasma and Therapeutic Concentrates (Ref. A221802, A221805, A221812)
• BIOPHEN Factor X - A New Way of Monitoring Warfarin - A Useful Tool for Monitoring Oral Anticoagulation Patients with Prolonged Pro-Times (Ref. A221705) 

Direct Xa Inhibitors 

• Specific and Rapid Measurement of Rivaroxaban in Plasma using a New, Dedicated, Chromogenic Assay
• BIOPHEN DiXaI Powerpoint (Ref. A221030)
• Laboratory Assays for New Anticoagulants used for Curative Indications 

Antithrombin III 

• Analysis of the AT III Effect in the BIOPHEN Heparin Device (Ref. 221003/ A221006)
• Measurement of Progressive Antithrombin (AT III) Activity) (Ref. A221102/A221105)

Prothrombin 

• Prothrombin Study Clotting vs Chromogenic Assay - BIOPHEN Prothrombin (Ref. A221605)

Activated Protein C Resistance

• Acceptance Range of Clotting Time for Act PC-r When using HEMOCLOT FV-L Device (ACK061K/L) with Water Bath or STA-R (Ref. A223405).

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3. ZYMUTEST

ZYMUTEST - Schemes

• Fibrinolysis - A Major but Under-Explored Anti-Thrombotic System, Which Disfunctions can Kill... Silently!
• Fibrinolysis and Thrombosis Enzyme Immuno Assays for the Exploration of Fibrinolysis in Human Plasma (Ref. ZYMUTEST line / Rat Immunochemicals / Rat Biochemicals)
• Assay Methods for the Exploration of Fibrinolysis
• Making Elisa Technology Simple Standardized, Optimized and Flexible-ZYMUTEST Line
• Exploring Fibrinolysis in the New Century
• The Most Comprehensive Line of ELISAS for Thrombosis, Hemostasis and Fibrinolysis 

Anti-Cardiolipin/Anti-Phospholipid Antibodies (ACA/APA)

• New Assays for Anti-Cardiolipin/Anti-Phospholipid Antibodies (ACA/APA) (Ref. ARK029A, ARK029B, ARK029C, ARK014A, ARK014B, ARK014C)
• Assays for Anti-Phospholipid Antibodies (ACA/APA) and Antibodies to Phospholipid Cofactors (Ref. ARK029A, ARK029B, ARK029C)
• New Assays for Anti-Cardiolipin/Anti-Phospholipid Antibodies (ACA-APA) (Ref. ARK005A, ARK005B, ARK007A, ARK007B, ARK014A, ARK014B, ARK014C, ARK020A, ARK020B, ARK025A, ARK025B, ARK026A, ARK026B, ARK029A, ARK029B, ARK029C)

Rat Fibrinolysis 

• Rat Fibrinolysis Reagents and Biochemicals Kits for Testing PAI-1 Antigen or Activity in Rat Plasma by ELISA Techniques (Ref. ARK001A / ARK003A)

Anti Annexin V 

• ZYMUTEST Annexin V Research Reagent - A New Reliable Assay for Measuring Annexin V in Human Plasma: Quality Control of Platelet and Blood Cell Concentrates (Ref. ARK004A)
• Annexin V Storage of Platelet and Blood Cell Concentrates (Ref. ARK004A)

High Sensitive Cross Reative Protein 

• High Sensitive Detection of Cross Reactive Protein (HS-CRP) by ELISA Technique - ZYMUTEST CRP-HS (Ref. ARK010A)

Fibrino-Peptide A 

• Assay of Fibrino-Peptide A (FPA) with a Competitive Enzyme Linked Immuno-Sorbent Assay (CELIA) - ZYMUTEST FPA (Ref. ARK016A)

Platelet Factor 4 

• Assay of Platelet Factor 4 by ELISA - ZYMUTEST PF4 (Ref.ARK006A)
• Two-site ELISA method for the measurement of human PF4 (platelet factor 4), on platelet poor human plasma, or any biological sample where PF4 must be measured (Ref. ARK006A)
• Platelet Factor 4 (PF4) is released from platelets upon activation and binds to endothelial cell glycosaminoglycans from where it can be displaced by heparin, then forming heparin-PF4 complexes.
• Scheme showing how heparin dependent antibodies, mainly targeted to Platelet Factor 4 (PF4) complexed with heparin, can activate platelets and endothelium, induce formation of platelets and platelet-leukocyte aggregates, and then lead to thrombus formation by complexed mechanisms also involving release of Tissue Factor (TF) from endothelial cells and monocytes (Ref. ARK006A, HIT Assays)
• Another Scheme showing how heparin dependent antibodies, mainly targeted to Platelet Factor 4 (PF4) complexed with heparin, can activate platelets and endothelium, induce formation of platelets and platelet-leukocyte aggregates, and then lead to thrombus formation by complexed mechanisms also involving release of Tissue Factor (TF) from endothelial cells and monocytes (Ref. ARK006A, HIT Assays)

Thrombin Activatable Fibrinolysis Inhibitors 

• ZYMUTEST TAFI - Enzyme Immune Assay of Thrombin Activatable Fibrinolysis Inhibitor in Human Plasma or Serum (Ref. ARK008A)
• Enzyme Immunoassays for the Exploration of Fibrinolysis in Human Plasma ZYMUTEST TAFI (Ref. ARK008A)

Von Wilebrand Factor 

• ZYMUTEST vWF Enzyme Immuno Assay for measuring Von Wilebrand Factor (Ref. ARK030A)

Cross-Reactivities with Animal Proteins

• Cross-Reactivities with Homologous Animal Proteins for the Various ZYMUTEST Kits
• ZYMUTEST Kits - Cross-Reactivities with Animal Proteins  

PAI-1 Activity

• New PAI-1 Activity Standard for ZYMUTEST PAI-1 Activity (ARK019A)

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4. HIT ASSAYS

• A New Test for the Diagnosis of Heparin Dependent Antibodies Associated With Type II Heparin Induced Thrombocytopenia (HIT) - Zymutest Hia (Ref. ARK040A / ARK040B / ARK040C / ARK040D / ARK040E)
• A New Concept for Diagnosis of Heparin Induced Thrombocytopenia (Hit) - ZYMUTEST Hia (Ref. ARK040A / ARK040B / ARK040C / ARK040D / ARK040E)
• Diagnosis of Heparin Induced Thrombocytopenia - HIT Assays (Ref. ARK040A / ARK040D / ARK040E)
• New Assays for HIT Diagnosis Based on the Understanding of Heparin Antigens Function - Heparin Induced Thrombocytopenia Slideshow (Ref. ARK040A / ARK040B / ARK040C / ARK040D/ ARK040E)
• Heparin Induced Thrombocytopenia - A Clinical Paradox (Ref. ARK040A / ARK040B / ARK040C / ARK040D/ ARK040E)
• New Approach for Detection Of Heparin Dependent Antibodies and Risk Assessment for Heparin Induced Thrombocytopenia - HIT Assays
• Incidence of the Various Heparin Dependent Antibody Isotypes in a Group of Patients With Heparin Induced Thrombocytopenia - HIT Assays
• Evaluation of a Rapid Particle Gel Immuno Assay (PaGIA) for Detection of Heparin/PF4 Antibodies (HPA) - HIT Assays
• Heparin Dependent Antibodies IgG Protocol (Ref. ARK040A)
• Global Heparin Dependent Antibodies Protocol (Ref. ARK040D)
• Improved Clinical Specificity of Heparin Induced Thrombocytopenia Immunoassay (Ref. ARK040A, ARK040B, ARK040C, ARK040D, ARK040E)
• Association of Protamine Sulfate Antibodies with "Pseudo-HIT" in Heparin Treated Patients (Ref. ARK040A, ARK040B, ARK040C, ARK040D, ARK040E)
• How the ZYMUTEST HIT Assays Outperform GTI and STAGO Kits
• ZYMUTEST HIA (IgG or IgGAM) "How to use" Flyer (Ref. ARK040A, ARK040D, ARK041A, ARK041D)
• Presentation with individual strips, small package (Ref. ARK041A, ARK041D)
• Antibodies to Protamine Sulfateor to its Complexes with Heparin can be the Sole Ones Identified in Some Patients with Suspicion of HIT.
• Heterogenity of Heparin Induced Antibody Profiles in Patients Suspected of Heparin Induced Thrombocytopenia (HIT).
• Mechanisms Involved in Heparin-Induced Thrombocytopenia and Associated Thrombosis - Anne Marie Vissac, M.T., and Jean Amiral, Ph.D. 2008

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5. MICROPARTICLES

• Functional or Immunological Assays for the Measurement of Microparticles on Plasma (Zymuphen MP-Activity Ref. A521096 and MP-TF)
• Procoagulant and Cell Derived Microparticles: Measurement in Plasma and Clinical Significance (Ref. A521096)
• Measurement of Procoagulant or Cell Derived Microparticles: Consequence and cause of disease - Zymuphen MP-Activity (Ref. A521096)
• Measurement of Microparticles Procoagulant Activity (Ref. A521096)
• Procoagulant Microparticles in Plasma - ZYMUPHEN MP-Activity (Ref. A521096)
• Procoagulant membrane microparticles correlate with the severity of pulmonary arterial hypertension abstract (Ref. A521096)
• Microparticles Procoagulant Activity in Citrated Plasma (Ref. A521096)
• Measurement of Procoagulant Potential of Blood Microparticles Carrying Tissue Factor (Ref. A521096)
• Microparticles and Fibrinolysis

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6. VETERINARY

• A New Sensitive, Specific, Patented ELISA for Testing Antibodies to Maedi Visna Virus (MVV) in Sheep or Goat Sera or Milk. (Ref. ACK104A, ACK105A, AVP001A, AVP002A, AVP003A)
• Evaluation of Five Enzyme-Linked Immunosorbent Assays and an Agar Gel Immunodiffusion Test for Detection of Antibodies to Small Ruminant Lentiviruses (Ref. ACK104A, ACK105A, AVP001A, AVP002A, AVP003A)
• A Sensitive, Specific, Patented ELISA for Detecting Antibodies to Maedi Visna Virus (MVV) in Sheep or Caprine Arthritis Encephalitis Virus in Goats (Ref. ACK104A, ACK105A, AVP001A, AVP002A, AVP003A)
• A New Sensitive Serological Assay for Detection of Lentivirus Infections in Small Ruminants (Ref. ACK104A, ACK105A, AVP101A, AVP102A, AVP103A)

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 7. Human, Bovine and Miscellaneous Sales Sheets

• Purified Bovine Enzymes-Biochemicals Product Lines (Ref. ABE101 series / ABE102 series / ABE501 series)
• Human Biochemicals-Biochemicals Product Lines (Ref. Purified Human Enzymes / Purified Human Protein / Vitamin K Dependent Proteins / Platelet Proteins / Recombinant Proteins / Miscellaneous)
• Purified Antibodies and Conjugates-Immunochemicals Product Lines (Ref. Polyclonal Antibodies / Monoclonal Antibodies / Immunoconjugates - Anti-Human & Anti Rabbit)
• Human Protein Test Results (Ref. APP001A/B/C/K/S - APP004A/B/C/D/K/L - APP017A - A221902)
• Vitamin K Dependent Test Results (Ref. APP006B / APP006K / APP007A / APP008A / APP012A / APP013A)
• Research and Diagnostic Reagents for Thrombosis-Haemostasis-Autoimmunity Brochure
• Activation, Regulation, Inhibition of Blood Coagulation
• A Complete Range of Laboratory Technologies for the Exploration of Haemostasis, Thombosis, Auto-Immune Disorders and Fibrinolysis

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8. Technical Files

Heparin Kits

• BIOPHEN Heparin Technical File (Ref. A221003 / A221006)
• BIOPHEN Heparin Anti-Xa (2 stages) USP/EP Technical File (Ref. A221010-USP)
• BIOPHEN  Heparin (LRT) Technical File (Ref. A221011)
• BIOPHEN Heparin Anti-IIa (2 Stages) - USP/EP Technical File (Ref. A221025-USP)

Chromogenic Kits

• BIOPHEN DiXaI (Direct Inhibitors) Technical File (Ref. A221030) 
• BIOPHEN Antithrombin (AT) Technical File (Ref. A221102/A221105) 
• BIOPHEN Protein C Technical File (Ref. A221202/A221205) 
• BIOPHEN Factor VIII:C Technical File (Ref. A221402/A221406) 
• BIOPHEN Plasminogen Technical File (Ref. A221502) 
• BIOPHEN Prothrombin Technical File (Ref. A221605) 
• BIOPHEN Factor X Technical File (Ref. A221705) 
• BIOPHEN H-CoII Technical File (Ref. A221902) 

CEPHEN Kits 

• CEPHEN Technical File (Ref. ACK511K, ACK512K, ACK515K, ACK515L, ACK521K & ACK522K)

HEMOCLOT Kits 

• HEMOCLOT Thrombin Inhibitors Technical File (Ref. ACK002K)
• HEMOCLOT Thrombin Time (T.T.) Technical File (Ref. ACK011K / ACK011L)
• HEMOCLOT Factor VL Technical File (Ref. ACK061K/ACK061L)

LIAPHEN Kits 

• LIAPHEN AT Technical File (Ref. A120002)
• LIAPHEN Fibrinogen Technical File (Ref. A120102)

ZYMUTEST Kits 

• ZYMUTEST tPA Antigen Technical File (Ref. ARK011A)
• ZYMUTEST PAI-1 Antigen Technical File (Ref. ARK012A)
• ZYMUTEST Anti B2GPI IgG/IgM Technical File (Ref. ARK014A/ARK014B)
• ZYMUTEST ACA-APA-IgG or IgM Isotype Technical File (Ref. ARK029A / ARK029B)

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9. Posters

• Antibodies to Phospholipid Cofactor Proteins Inhibit their Binding to High Affinity PLPS but Strongly Enhance their Binding to Low Affinity PLPS (Ref. ARK004A, ARK022A)
• Binding of B2GP1 to Various Phospholipid Mixtures is Calcium Dependent and is Dramatically Enhanced by Antibodies: Understanding the Anticoagulant Paradox (Ref. ARK022A)
• A Novel, Specific and Quantitative Assay for Measuring Factor V-LEIDEN, with a Single Step Clotting Method (Ref ACK061K, ACK061L)
• Measurement of Hirudin and Synthetic Thrombin Inhibitors in Plasma with a New Clotting Method, without Interference of Clotting Factor Levels (Ref. ACK002K)

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10. Evaluation of Hyphen BioMed Chromogenic Substrates vs Chromogenix Substrates

• Evaluation of chromogenic substrates: Hyphen BioMed vs Chromogenix - All Substrates
• Comparison of Characteristics and Performances of Thrombin Chromogenic Substrates: Hyphen BioMed CS-01(38) vs Chromogenix S2238 (Ref. A229001, A229001-100, A229001-1, A229001-5)
• Comparison of Characteristics and Performances of FXa Chromogenic Substrate: Hyphen BioMed CS-11(22) vs Chromogenix S2222 (Ref. A229015, A229115, A229015-1, A229015-5)
• Comparison of Characteristics and Performance of FXa Chromogenic Substrate: Hyphen BioMed CS-11(32) vs Chromogenix S2732 (Ref. A229011, A229011-100, A229011-1, A229011-5)
• Comparison of Characteristics and Performances of FXa Chromogenic Substrate : Hyphen BioMed CS-11(65) vs Chromogenix S2765 (Ref. A229014, A229014-100, A229014-1, A229014-5)
• Comparison of Characteristics and Performances of Activated Protein C (aPC) Chromogenic Substrate: Hyphen BioMed CS-21(66) vs Chromogenix S2366 (Ref. A229021, A229021-100, A229021-1, A229021-5)
• Comparison of Characteristics and Performances of Kallicrein Chromogenic Substrate: Hyphen BioMed CS-31(02) vs Chromogenix S2302 (Ref. A229031, A229031-100, A22931-1, A229031-5)
• Comparison of Characteristics and Performances of Plasmin/Plasminogen-SK Chromogenic Substrate: Hyphen BioMed CS-41(03) vs Chromogenix S2403 (Ref. A229041, A229041-100, A229041-1, A229041-5)
• Characteristics and Performances of FIXa Chromogenic Substrate: Hyphen BioMed CS-51(09) (Ref. A229051, A229051-100, A229051-1, A229051-5)
• Comparison of Characteristics and Performances of Urokinase (uPA) Chromogenic Substrate: Hyphen BioMed CS-61(44) (Ref. A229061, A229061-100, A229061-1, A229061-5)

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11. INDUSTRIAL USP HEPARIN REAGENTS

• Summary of Validation Criteria for Chromogenic Substrates (Especially CS-11(65) and CS-01(38)) for Human Antithrombin, Human Thrombin, Bovine FXa.

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12. Product Catalogs

• Hyphen BioMed Product/Price List
• Hyphen BioMed Product Catalog
• Hyphen BioMed Corporate Presentation

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