Resources
Literature
Product Lines
Hyphen-BioMed Product Literature
HEMOCLOT 
- Updating Conventional Clotting Assays - HEMOCLOT Line
- The Central Role of Thrombin in Regulating Coagulation - Calibrators and Controls (Ref. ACK001K / ACK001L)
- True Anti-Thrombin Clotting Activity of Direct Thrombin Inhibitors in Plasma Including Argatroban® (Ref. ACK002K)
- Direct Thrombin Inhibitors' Activity Measurement in Plasma (ref. ASC030K, ASC035K, ACK002K, A220202)
- New Assays for Safely Monitoring Hirudin and Direct Thrombin Inhibitors
- Highly Sensitive Assay for Measuring Factors VII+X in Human Plasma - HEMOCLOT VII+X (Ref. ACK051K)
- The Reagent of Choice for all your Thrombin Time Applications - HEMOCLOT Thrombin time (T.T.) (Ref. ACK011K / ACK011L)
- The Most Updated Clotting Methods (Ref. ADP080A, ADP080K, ADP070A, ADP070K, ADP060A, ADP060K, ADP050A, ADP050K, ADP040A, ADP040K, ADP030A, ADP030K, ADP020A, ADP020K, ADP010A, ADP010K, ACK081K, ACK071K, ACK065K, ACK061K, ACK061L, ACK011K, ACK011L, ACK002K, ACK001K, ACK001L)
- Regulation of Blood Coagulation Through the Protein C / Protein S and AT lll Pathways - Quanti V-L (Ref. ACK065K)
- Measuring the APC Resistance associated with Factor V-L, Quantitatively - New Concept for Factor V-L (Ref. ACK065K / ACK065L)
- Measuring the APC Resistance associated with Factor V-L (Ref. ACK061K / ACK061L)
- Quantitative Assay for Measuring Factor V-Leiden Concentration in Plasma by its Resistance to the Action of Activated Protein C - Hemoclot Quanti-V-L (Ref. ACK065K)
- New Quantitative Assay for Factor V-Leiden - Measuring APC Ressistance Associated with Factor V-Leiden Quantitatively (Ref. ACK061K/ACK061L)
- Quantitative Measurement Of Factor V-Leiden With a New, One Step, Calibrated, Clotting Assay (Ref. ACK061K/ACK061L)
- Classification of Factor V-Leiden Carriers by Quantitatively Measuring it's Procoagulant Activity Comparatively to that of Factor V (Ref. ACK065K, ACK061K, ACK071K and ARK009A)
- Quantitative Measurement of Factor V Leiden in Heterozygous and Homozygous Patients for the R506Q Factor V Mutation (Ref. ACK065K, ACK061K, ACK071, ARK009A)
- Evaluation of a Novel Quantitative Assay for Factor V Leiden (Ref. ACK065K)
- The Modern Approach for Clotting Assays
- A New Sensitive, Specific, Patented ELISA
For Testing Antibodies to Maedi Visna Virus (MVV) in Sheep
or Goat Sera or Milk - (Ref.ACK104A/ACK105A)
BIOPHEN 
- Laboratory Assays for Anticoagulant/Antithrombotic Proteins (Ref. A221202, A221205, A221102, A221105, A222101, A223201 A223301)
- Prothrombin Study Clotting vs Chromogenic Assay - BIOPHEN Prothrombin (Ref. A221605)
- BIOPHEN Factor X - A New Way of Monitoring Warfarin - A Useful Tool for Monitoring Oral Anticoagulation Patients with Prolonged Pro-Times (Ref. A221705)
- BIOPHEN VIII:C, Factor VIII:C Chromogenic assay - A Reference Method, Which Can Be Used With Manual or Automated Techniques (Ref. A221402)
- Measurement of Factor VIII:C Activity in Human Plasma or in Factor VIII :C Concentrates (Ref. A221402)
- Factors Affecting the Factor VIII:C Reactivity When Tested in Purified Systems With Chromogenic Assays (Ref. A221402)
- A Complete Line of Chromogenic Assays (Ref. A221402, A221304, A221202, A221205, A221705, A221605, A221102, A221105, A221111, A221003,A221006, A221505, A222101, A223201, A223301)
- The Most Complete Range of Chromogenic Assays for Heparin
- Hyphen BioMed Offers a Complete Range of Kits for Measuring Heparin Concentrations (Ref. A221003, A221006,A221010, A221020, A221025, A222001, A222301, A222201, A223001, 223701, 223101, A223501, A222501, A224001, ARK040A, ARK040D, ARK040E)
- Measurement of Heparin Concentrations in Human Plasma Concentrations (Ref. A221003 / A221006)
- Analysis of the AT III Effect in the BIOPHEN Heparin Device (Ref. 221003/ A221006)
- Comparison of Two Anti-Xa Heparin Assays That Use a Single (Hybrid) Calibration Curve for Unfractionated and Low Molecular Weight Heparin (Ref. A221010)
- New Standardized Chromogenic Assays for Automated Measurements of FIX or FIXa in Plasma and Therapeutic Concentrates (Ref. A221802, A221805, A221812)
- Acceptance Range of Clotting Time for Act PC-r When using HEMOCLOT FV-L Device (ACK061K/L) with Water Bath or STA-R (Ref. A223405).
- BIOPHEN DiXia Powerpoint (Ref. A221030)
- Laboratory Assays for New Anticoagulants used for Curative
Indications
- Specific and Rapid Measurement of Rivaroxaban in Plasma using a New, Dedicated, Chromogenic Assay
ZYMUTEST 
- New Assays for Anti-Cardiolipin/Anti-Phospholipid Antibodies (ACA-APA) (Ref. ARK029A, ARK029B, ARK029C, ARK014A, ARK014B, ARK014C)
- Assays for Anti-Phospholipid Antibodies (ACA/APA) and Antibodies to Phospholipid Cofactors (Ref. ARK029A, ARK029B, ARK029C)
- New Assays for Anti-Cardiolipin/Anti-Phospholipid Antibodies (ACA-APA) (Ref. ARK005A, ARK005B, ARK007A, ARK007B, ARK014A, ARK014B, ARK014C, ARK020A, ARK020B, ARK025A, ARK025B, ARK026A, ARK026B, ARK029A, ARK029B, ARK029C)
- Rat Fibrinolysis Reagents and Biochemicals Kits for Testing PAI-1 Antigen or Activity in Rat Plasma by ELISA Techniques (Ref. ARK001A / ARK003A)
- ZYMUTEST Annexin V Research Reagent - A New Reliable Assay for Measuring Annexin V in Human Plasma: Quality Control of Platelet and Blood Cell Concentrates (Ref. ARK004A)
- Annexin V Storage of Platelet and Blood Cell Concentrates (Ref. ARK004A)
- High Sensitive Detection of Cross Reactive Protein (HS-CRP) by ELISA Technique - ZYMUTEST CRP-HS (Ref. ARK010A)
- Assay of Fibrino-Peptide A (FPA) with a Competitive Enzyme Linked Immuno-Sorbent Assay (CELIA) - ZYMUTEST FPA (Ref. ARK016A)
- Assay of Platelet Factor 4 by ELISA - ZYMUTEST PF4 (Ref.ARK006A)
- Two-site ELISA method for the measurement of human PF4 (platelet factor 4), on platelet poor human plasma, or any biological sample where PF4 must be measured (Ref. ARK006A)
- Platelet Factor 4 (PF4) is released from platelets upon activation and binds to endothelial cell glycosaminoglycans from where it can be displaced by heparin, then forming heparin-PF4 complexes.
- Scheme showing how heparin dependent antibodies, mainly targeted to Platelet Factor 4 (PF4) complexed with heparin, can activate platelets and endothelium, induce formation of platelets and platelet-leukocyte aggregates, and then lead to thrombus formation by complexed mechanisms also involving release of Tissue Factor (TF) from endothelial cells and monocytes (Ref. ARK006A, HIT Assays)
- Another Scheme showing how heparin dependent antibodies, mainly targeted to Platelet Factor 4 (PF4) complexed with heparin, can activate platelets and endothelium, induce formation of platelets and platelet-leukocyte aggregates, and then lead to thrombus formation by complexed mechanisms also involving release of Tissue Factor (TF) from endothelial cells and monocytes (Ref. ARK006A, HIT Assays)
- ZYMUTEST TAFI - Enzyme Immune Assay of Thrombin Activatable Fibrinolysis Inhibitor in Human Plasma or Serum (Ref. ARK008A)
- Enzyme Immunoassays for the Exploration of Fibrinolysis in Human Plasma ZYMUTEST TAFI (Ref. ARK008A)
- Fibrinolysis - A Major but Under-Explored Anti-Thrombotic System, Which Disfunctions can Kill... Silently!
- ZYMUTEST vWF Enzyme Immuno Assay for measuring Von Wilebrand Factor Ref. (ARK030A)
- Fibrinolysis and Thrombosis Enzyme Immuno Assays for the Exploration of Fibrinolysis in Human Plasma (Ref. ZYMUTEST line / Rat Immunochemicals / Rat Biochemicals)
- Assay Methods for the Exploration of Fibrinolysis
- Making Elisa Technology Simple Standardized, Optimized and Flexible-ZYMUTEST Line
- Exploring Fibrinolysis in the New Century
- The Most Comprehensive Line of ELISAS for Thrombosis, Hemostasis and Fibrinolysis
- Cross-Reactivities with Homologous Animal Proteins for the Various ZYMUTEST Kits
- ZYMUTEST Kits - Cross Reactivities with Animal Proteins

HIT ASSAYS 
- A New Test for the Diagnosis of Heparin Dependent Antibodies Associated With Type II Heparin Induced Thrombocytopenia (HIT) - Zymutest Hia (Ref. ARK040A / ARK040B / ARK040C / ARK040D / ARK040E)
- A New Concept for Diagnosis of Heparin Induced Thrombocytopenia (Hit) - ZYMUTEST Hia (Ref. ARK040A / ARK040B / ARK040C / ARK040D / ARK040E)
- Diagnosis of Heparin Induced Thrombocytopenia - HIT Assays (Ref. ARK040A / ARK040D / ARK040E)
- New Assays for HIT Diagnosis Based on the Understanding of Heparin Antigens Function - Heparin Induced Thrombocytopenia Slideshow (Ref. ARK040A / ARK040B / ARK040C / ARK040D/ ARK040E)
- Heparin Induced Thrombocytopenia - A Clinical Paradox (Ref. ARK040A / ARK040B / ARK040C / ARK040D/ ARK040E)
- New Approach for Detection Of Heparin Dependent Antibodies and Risk Assessment for Heparin Induced Thrombocytopenia - HIT Assays
- Incidence of the Various Heparin Dependent Antibody Isotypes in a Group of Patients With Heparin Induced Thrombocytopenia - HIT Assays
- Evaluation of a Rapid Particle Gel Immuno Assay (PaGIA) for Detection of Heparin/PF4 Antibodies (HPA) - HIT Assays
- Heparin Dependent Antibodies IgG Protocol (Ref. ARK040A)
- Global Heparin Dependent Antibodies Protocol (Ref. ARK040D)
- Improved Clinical Specificity of Heparin Induced Thrombocytopenia Immunoassay (Ref. ARK040A, ARK040B, ARK040C, ARK040D, ARK040E)
- Association of Protamine Sulfate Antibodies with "Pseudo-HIT" in Heparin Treated Patients (Ref. ARK040A, ARK040B, ARK040C, ARK040D, ARK040E)
- How the ZYMUTEST HIT Assays Outperform GTI and STAGO Kits
- ZYMUTEST HIA (IgG or IgGAM) "How to use" Flyer (Ref. ARK040A, ARK040D, ARK041A, ARK041D)
- Presentation with individual strips, small package (Ref. ARK041A, ARK041D)
- Antibodies to Protamine Sulfateor to its Complexes with Heparin can be the Sole Ones Identified in Some Patients with Suspicion of HIT.
- Heterogenity of Heparin Induced Antibody Profiles in Patients Suspected of Heparin Induced Thrombocytopenia (HIT).
MICROPARTICLES 
Human, Bovine and Miscellaneous Sales Sheets 
Technical Files 
Posters 
Evaluation of Hyphen BioMed Chromogenic Substrates vs Chromogenix Substrates 
- Evaluation of chromogenic substrates: Hyphen BioMed vs Chromogenix - All Substrates
- Comparison of Characteristics and Performances of Thrombin Chromogenic Substrates: Hyphen BioMed CS-01(38) vs Chromogenix S2238 (Ref. A229001, A229001-100, A229001-1, A229001-5)
- Comparison of Characteristics and Performances of FXa Chromogenic Substrate: Hyphen BioMed CS-11(22) vs Chromogenix S2222 (Ref. A229015, A229115, A229015-1, A229015-5)
- Comparison of Characteristics and Performance of FXa Chromogenic Substrate: Hyphen BioMed CS-11(32) vs Chromogenix S2732 (Ref. A229011, A229011-100, A229011-1, A229011-5)
- Comparison of Characteristics and Performances of FXa Chromogenic Substrate : Hyphen BioMed CS-11(65) vs Chromogenix S2765 (Ref. A229014, A229014-100, A229014-1, A229014-5)
- Comparison of Characteristics and Performances of Activated Protein C (aPC) Chromogenic Substrate: Hyphen BioMed CS-21(66) vs Chromogenix S2366 (Ref. A229021, A229021-100, A229021-1, A229021-5)
- Comparison of Characteristics and Performances of Kallicrein Chromogenic Substrate: Hyphen BioMed CS-31(02) vs Chromogenix S2302 (Ref. A229031, A229031-100, A22931-1, A229031-5)
- Comparison of Characteristics and Performances of Plasmin/Plasminogen-SK Chromogenic Substrate: Hyphen BioMed CS-41(03) vs Chromogenix S2403 (Ref. A229041, A229041-100, A229041-1, A229041-5)
- Characteristics and Performances of FIXa Chromogenic Substrate: Hyphen BioMed CS-51(09) (Ref. A229051, A229051-100, A229051-1, A229051-5)
- Comparison of Characteristics and Performances of Urokinase (uPA) Chromogenic Substrate: Hyphen BioMed CS-61(44) (Ref. A229061, A229061-100, A229061-1, A229061-5)
Product Catalog 
Xenometrix Product Literature
AMES and INCYTOTOX - Instructions for use 
Ames MPF Liquid Kits
Ames MPF Semi-Solid Kits
One Parameter 
Two Parameter 
Three Parameter 
Four Parameter 
Posters/Sales Sheets 
- Ames MPF Mutagenicity Assay Technical Documentation
- Genotoxicity Testing Ames MPF Fluctuation Assays and Cytotoxicity Screening IN CYTOX Cytotoxicity Test Systems
- Ames MPF 98/100 Assay: Novel Mutagenicity Testing In Liquid Microplate Format Using S. typhimurium TA98 and TA100 - Ames MPF 98/100 Assay - Ref. ATAM-98-100-1, ATAM-98-100-10, ATAM-98-100-pw
- Ames MPF 98/100 Assay: Novel Mutagenicity Testing in Liquid Microplate Format using S typhimurium TA98 and TA100 - Overview
- Ames MPF 98/100 Assay - Process and Advantages - Ref. TA98, TA100, TA1535 & TA1537
- Ames MPF - Testing in Liquid Microplate Format using S.typhimurium TA98, TA100, TA1535 and TA1537 Ames MPF Assays
- How to use the Ames MPF Assay
- Bacterial Reverse Mutation - Ames MPF Test - Mutagenic Assay
- Ames MPF: New Optional Strain Handling to Reduce the Risk of Occasional Elevated Baseline Values
- Salmonella/Human S9 Mutagenicity Test: A Collaborative Study with 58 Compounds
- Effect-Directed Analysis of Mutagenic Polyaromatic Compounds in Sediment Extracts
- Detection and Classification of Mutagens: A Set of Base-Specific
Salmonella Tester Strains
- Ames II Mutagenicity Assay Technical Documentation
- Ames II Mutagenicity Assay: An International Validation Study Performed with Nineteen Coded Compounds
- Assessment of the Performance of the Ames II Assay: A Collaborative Study with 19 Coded Compounds - Abstract and Results
- Ames II Assay: Results of a Validation Study
- Bacterial Reverse Mutation - Ames II Test Mutagenic Assay
- Comparison of Pre-Assay Clean-up Procedures for Unveiling the Mutagenic Potency of Sediment Extracts
- Automation of the AMES II-Assay:
High-Throughput Screening of Mutagenic Substances
- Ames Product Information Request Form
- Ames Easy Assays Information Request Form
- Evaluation of a Battery of
Early Genotoxicity Assays
to Predict Regulatory Testing
- The AMES MPF PENTA I Assay: Mutagenicity Testing in Liquid Microplate Format Using OECD Guideline 471 Compliant Strains S. typhimurium TA98, TA100, TA1535, TA1537 and E.coli WP2 uvrA plus E.coli WP2 [pKM101]
- Historic solvent control values (DMSO) for the PENTA I strains
- Comparison of the Ames II and traditional Ames test responses with respect to
mutagenicity, strain specificities, need for metabolism and correlation with rodent
carcinogenicity
- Short Ames MPF Assay Description
- Research Article: Comparison of the Salmonella / Microsome
Microsuspension Assay with the newMicroplate
Fluctuation Protocol for Testing the Mutagenicity of
Environmental Samples
- Rapid Mutagenicity Testing by
Xenometrix: UmuC Easy AQ
and
UmuC Easy CS
- Water quality - Determination of the
genotoxicity of water and waste water
using the umu-test
- Water quality - Determination of the genotoxicity of water and waste
water- Salmonella/microsome fluctuation test (Ames fluctuation test)
- Mutagenic Responses in the Xenometrix Ames MPF PENTA I Assay Compared to Published Ames Plate Incorporation Data
- CelTox Software Manual
- CelTox Software Tutorial
- Calculation Sheet for Ames ll and Ames MPF Assays

- Calculation Sheet for Ames umuC Easy AQ Assays

- Calculation Sheet for Ames umuC Easy CS Assays

IN CYTOTOX - Sales Sheets
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