Heparin and protease neutralizer reagents from 5-Diagnostics for eliminating interfering substances in plasma-based coagulation and chromogenic substrate assay systems.
Residual heparin in plasma at concentrations exceeding assay tolerance will inhibit both chromogenic substrate cleavage and clotting endpoint reactions — producing suppressed or inaccurate results in pharmacopoeial potency assays and chromogenic coagulation protocols.
5-Diagnostics heparin neutralizers include protamine sulfate and polybrene (hexadimethrine bromide) at validated concentrations, formulated for complete neutralization in plasma matrices without disrupting coagulation factor activity.
Protamine sulfate is the standard heparin neutralizing agent for pharmacopoeial QC applications; polybrene provides an alternative for protocols where protamine sulfate interference is a concern.
Serine protease inhibitor preparations are available for pharmaceutical manufacturing applications requiring broad-spectrum protease suppression — particularly relevant in FIX concentrate and recombinant coagulation factor production where contaminating protease activity must be controlled prior to lot release testing.
All preparations are supplied with validated use protocols and lot-specific activity data. For Research Use Only. Not for use in diagnostic procedures.