Alpha2-Antiplasmin

Alpha-2-antiplasmin (α2-AP) deficient plasma from 5-Diagnostics for fibrinolysis research and plasmin inhibitor pathway studies.

Alpha-2-antiplasmin is the primary and most rapidly acting physiological inhibitor of plasmin — it forms an irreversible covalent complex with plasmin immediately upon plasmin generation, limiting the duration and extent of fibrinolysis. α2-AP is also cross-linked to fibrin by Factor XIIIa during clot formation, providing local protection of the clot from premature fibrinolytic attack.

Inherited α2-antiplasmin deficiency is a rare bleeding disorder associated with hyperfibrinolysis and abnormal clot lysis — making α2-AP deficient plasma a key tool for studying the contribution of this inhibitor to overall fibrinolytic regulation.

5-Diagnostics α2-AP deficient plasma is produced by immunodepletion of alpha-2-antiplasmin from large-pool human citrated plasma, with residual α2-AP activity confirmed below 1% of normal by chromogenic substrate assay.

Used in clot lysis time assays (euglobulin lysis, plasma clot lysis assay) to study the contribution of α2-AP to clot stability, in α2-AP activity assay calibration by reconstruction experiments, and in research characterizing the fibrinolytic response to thrombolytic agents. For Research Use Only. Not for use in diagnostic procedures.