Convulxin from 5-Diagnostics is a purified glycoprotein from the venom of Crotalus durissus terrificus (South American rattlesnake) that functions as a potent and highly selective agonist of the platelet GPVI collagen receptor.
Convulxin binds GPVI directly and induces full platelet activation including shape change, dense granule secretion, and aggregation through the FcgR chain-Syk-LAT signaling axis — without activating other collagen-responsive platelet receptors (integrin alpha-2-beta-1, GPIb). This selectivity makes convulxin the preferred research tool for isolating GPVI-specific signaling events from the broader collagen response, enabling mechanistic studies of the GPVI pathway in platelet function research and thrombosis biology.
Light transmission aggregometry (LTA) with convulxin produces a concentration-dependent aggregation response specifically blocked by anti-GPVI antibodies or Syk inhibitors — useful for pharmacological characterization of compounds targeting the GPVI axis.
Available exclusively through Aniara in North America, convulxin from 5-Diagnostics is supplied as a lyophilized preparation with defined specific activity verified by platelet aggregation response. GPVI is a validated target for antiplatelet drug development; convulxin is the standard in vitro pharmacological tool for GPVI inhibitor screening. For Research Use Only. Not for use in diagnostic procedures.