Plasminogen-deficient substrate plasma from 5-Diagnostics for fibrinolytic pathway research and assay development requiring selective depletion of the plasminogen/plasmin axis.
Plasminogen is the central zymogen of the fibrinolytic system — converted to the active serine protease plasmin by tissue plasminogen activator (tPA) and urokinase (uPA). Plasminogen-deficient plasma is used as a control matrix to confirm assay specificity for plasmin-dependent endpoints, as a substrate for calibrating plasminogen activity assays, and in fibrinolysis research to isolate the contribution of plasminogen-independent fibrin degradation pathways.
5-Diagnostics plasminogen-deficient plasma is produced by affinity depletion of plasminogen from large-pool human citrated plasma using lysine-Sepharose affinity chromatography, which specifically removes plasminogen via its lysine-binding kringle domains while preserving activity of other coagulation and fibrinolytic proteins.
Residual plasminogen is confirmed below 1% of normal by chromogenic substrate assay. Compatible with clotting endpoint, chromogenic, and turbidimetric fibrinolysis assay systems including euglobulin clot lysis time (ECLT) and global fibrinolytic capacity (GFC) methods.Lyophilized format; lot-specific certificates include residual plasminogen activity (IU/mL), tPA activity verification, and matrix protein stability data. For Research Use Only. Not for use in diagnostic procedures.
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A5D-42154L
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Human Plasminogen Deficient Plasma, Lyophilized | $88.00 |