BIOPHEN™ chromogenic activity assays from HYPHEN BioMed for the two key functional components of the fibrinolytic system.
BIOPHEN™ Plasminogen LRT measures plasminogen activity using streptokinase to convert patient plasminogen to plasmin, which then cleaves a chromogenic substrate.
Plasminogen deficiency is associated with ligneous conjunctivitis (Type I hypoplasminogenaemia) and impaired wound healing; acquired deficiency occurs in DIC, thrombolytic therapy, and severe liver disease.
BIOPHEN™ α2-Antiplasmin LRT measures α2-antiplasmin activity — the primary rapid inhibitor of plasmin. α2-AP deficiency causes hyperfibrinolysis with delayed bleeding after trauma or surgery; elevated levels may contribute to impaired fibrinolysis and thrombotic risk.