PB/β-Naphthoflavone-Induced Hamster Liver S9 Fraction — 1 mL Liquid
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PB/β-Naphthoflavone-Induced Hamster Liver S9 Fraction — 1 mL Liquid

Code: APRS-H-PB01LIQ
Manufacturer’s Part Number: PRS-H-PB01LIQ
Product size: 1 ml, frozen liquid
Clearance: RUO

Price: $127.00

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Product Description

For Research Use Only. Not for Use in Diagnostic Procedures.

PB/β-Naphthoflavone (phenobarbital/β-naphthoflavone)-induced Hamster Liver S9 fraction, liquid format. 1 mL. Post-mitochondrial supernatant pooled from Golden Syrian Hamster livers with broad cytochrome P450 enzyme coverage via dual PB/β-NF co-induction.

Hamster liver S9 has a distinct cytochrome P450 enzyme profile compared to rat S9, particularly relevant for compounds that undergo species-specific bioactivation. Hamster S9 is used preferentially in the Enhanced Ames Test (OECD 471) for nitrosamines and in ADME pharmacokinetic studies for pharmaceutical preparations where hamster metabolic activation is required.

  • For Ames MPF, Ames II, umuC, and micronucleus genotoxicity assays
  • Complementary metabolic profile to standard rat S9
  • Preferred for nitrosamines per OECD 471
  • Liquid format — no reconstitution required. 1 mL.

Product Characteristics

  • Protein Concentration: 25 - 35 mg/ml
  • High activities of Cytochrome P450: 1A2 (MROD), 1A1, 1A2 (EROD), 3A, 2B (BROD), 2B1, 2B2 (PROD)
  • Storage: -20 or -80 oC
  • Shipment on dry ice from storage in Germany or from Switzerland
  • Shelf Life: 12 -24 months
  • In full compliance with OECD 471 guideline, ICH M7
  • Requested volumes in different Ames test: 0.44 mL/strain/compound in MicroAmes24, 0.35 mL/strain/ compound in Ames MPF, 1.4 mL / strain/ compound in Ames agar plate Test

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Product Applications

Instructions For Use

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Certificate of Analysis (COA)

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