2021 Winner
We are proud to announce the winner of our 2020 Coagulation Research Grant -
She now has $10,000 to use towards her project: Fibrin(ogen) fragments as a novel mediator of endotheliopathy during critical illness.
Congratulations, Jessica!
2020 Winner
We are proud to announce the winner of our 2020 Coagulation Research Grant -
He now has $10,000 to use towards his project: Complement -mediated inflammation and coagulation in SARS-CoV-2 infection.
Congratulations, Saravanan!
2017 Winners
We are proud to announce the winners of our 2017 Coagulation Research Grant -
They now have $20,000 to use towards their project researching EDS - Ehlers-Danlos syndrome — and its effects on hemostasis and thrombosis.
Congratulations, Christina and Rohith!
2015 Winner
We are proud to announce the winner of our 2015 Coagulation Research Grant -
He now has $10,000 to use towards his project, called "Thrombosuppressive mechanisms of an ARP2 mutant discovered through a mouse ENU mutagenesis screen."
Congratulations, Randal!
2013 Winner
Aniara is happy to announce the winner of the 2013 Aniara grant in the amount of $10,000 -
Luigi Brunetti, Clinical Assistant Professor, Rutgers University, Piscataway, NJ.
Congratulations, Luigi!
2012 Winner
Aniara is happy to announce the winner of the 2012 Aniara grant in the amount of $10,000 -
Dr. Paton joined the faculty at Texas Tech University in 2011 after completing his postdoctoral training at the University of Wisconsin-Madison in the department of Biochemistry.
While at UW, his work was focused on developing mouse and cell based models of diet induced obesity to study the regulation of lipid metabolism. Prior to that, he was a postdoctoral fellow at the Blood Research Institute in Milwaukee, WI investigating the mechanisms by which fibrin degradation products caused cell death. He completed his PhD at the University of Maryland in College Park (2005) and undergraduate work at Michigan State University (2000).
Abstract
Fibrin fragment-E mediated induction of adipose tissue inflammation.
We suspect that fibrin degradation products may be mediating adipocyte inflammation and subsequent insulin resistance and an early event in the development of glucose intolerance is adipose inflammation. Fibrin deposition is well known to induce local inflammation; however it has yet to be demonstrated to contribute to obesity induced adipose inflammation. Therefore, the purpose of this project is to establish the ability of fibrin degradation product E-fragment (FDP-E) to induce inflammation in macrophages and adipocytes. To test this concept, we will first determine the effect of FDP-E on macrophage inflammation by assessing M1 and M2 phenotypes and cytokine production in the presence of various concentrations of FDP-E. Next, we will evaluate the ability of exogenous FDP-E injected into the adipose tissue of mice to stimulate adipocyte inflammation and induce macrophage activation. This project is intended to define the role of FDP-E on adipose tissue inflammation and will establish fibrinogen, FDP-E, and thrombosis as primary causes of adipose tissue dysfunction with obesity.