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Monday, April 5, 2010



Cardiovascular Safety in Drug Development: QT, Arrhythmias, Thrombosis, and Bleeding

Date(s) And Time(s):
Apr 11 2010 8:00AM - Apr 13 2010 5:00PM

Sheraton National Hotel Arlington
900 South Orme Street
Arlington, VA 22204

Interest Area(s):
Clinical Safety/Pharmacovigilance, Clinical Research, Document Management/ eSubmissions, Nonclinical, Quality Assurance/Quality Control, Regulatory Affairs, Research & Development

Co-sponsored by the FDA and the Heart Rhythm Society
Abstract Submission Guidelines
Drug Development and CV safety
- Drug-induced increases in CV events
- Myocardial toxicity
- Pharmacogenomics and drug-induced CV injury
- How can we practically assess the negative inotropic potential of new drugs?
- Anticoagulant safety-how to measure it?
Evolving Science of

Learning Objectives:
At the conclusion of this conference, participants should be able to:
- Recognize the state-of-the-art approach to performing the thorough QT study, including double-blinding of the positive control agent, the statistical analysis of the positive control, the definition of adequate assay sensitivity, and issues of multiplicity
- Describe how to evaluate drugs for CV risk
- Explain how new preclinical or clinical biomarkers can gain regulatory acceptance;
- Identify how to optimally use preclinical data to assess CV risk
- Discuss the use of automatic QT

American Society for Clinical Laboratory Science -
New Jersey
is proud to present 2010 Spring Seminar & Industry Expo
Thursday, April 15, 2010
The Forge Inn
1002 Route 9 North
Woodbridge, New Jersey 07095
10:05-11:05 Heparin Induced Thrombocytopenia...To Follow
Intermediate Larry Smith, Ph.D., SH(ASCP), HCLD(ABB)
1.0 Contact hr. Director, Coagulation and Hemostasis Laboratories
Memorial Sloan-Kettering Cancer Center
We gratefully acknowledge Memorial Sloan-Kettering Cancer Center for support of this
This presentation will provide a review of heparin-induced thrombocytopenia (HIT). It will discuss the pathophysiology and clinical manifestation of HIT, and how laboratory tests are utilized to achieve its diagnosis.

11:10-12:10 Case Studies in Coagulation
Intermediate Donna D. Castellone, MS, MT(ASCP)SH
1.0 Contact hr. Clinical Project Manager, Hematology/Hemostasis
Siemens Healthcare Diagnostics
We gratefully acknowledge Siemens Healthcare Diagnostics for support of this
This presentation will look at some common and not so common case studies in the coagulation laboratory. A step by step approach will be used to analyze available information to aid in the identification of coagulation disorders. Cost effective testing patterns will also be reviewed

2010 Annual Scientific Symposium of the Hemophilia & Thrombosis Research Society and North American Specialized Coagulation Laboratory Association
Meeting: Thursday, April 15, 2010 to Saturday, April 17, 2010

Program Description
On behalf of the 2010 Planning Committee, we are pleased to announce the program for the joint
HTRS/NASCOLA Scientific Symposium. Based on the overwhelming success of our 2008 collaboration, the Hemophilia and Thrombosis Research Society (HTRS at and the North American Specialized Coagulation Laboratory Association (NASCOLA at have once again joined forces to create an exciting program with a mixture of symposia covering clinical, basic science, and laboratory topics in hemostasis and thrombosis.

This year's program features simultaneous symposia, as well as special sessions for nurses. Eight symposia will be presented in 6 time slots (4 stand-alone symposia and 4 running concurrently). We have incorporated 2 breakout symposia chaired by the nursing representatives on our planning committee. All HTRS members should encourage their nurses and physician assistants to attend and take advantage of this specialized content.

Lastly, we are honored to welcome 2 outstanding international speakers to this year's meeting. Dr. Alessandro Gringeri is a noted authority on hemophilia who will speak not only during the symposia but also at the Friday night social event. Dr. Guido Finazzi is an expert on thrombosis in myeloproliferative disorders and an excellent speaker as well. We hope you will join us in welcoming these speakers along with our entire distinguished faculty. We look forward to a very productive and stimulating meeting.

For complete registration and meeting information please access

Northwestern Memorial Hospital
Chicago, Illinois

Accessible Services

Clotter's Links


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Donna Castellone

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Donna Castellone,  MS, MT(ASCP)SH

Donna Castellone,

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